This study evaluated a time-restricted region-suppressed event-related synthetic aperture magnetoencephalography (TRRS-ER-SAM) beamformer algorithm against equivalent current dipole (ECD), and event-related synthetic aperture magnetoencephalography (ER-SAM) post-processing methods for magnetoencephalography data. This evaluation was done numerically and with auditory evoked field (AEF) data elicited by binaurally presented 500 Hz tones. The TRRS-ER-SAM beamformer demonstrated robustness to noise, and the ability to handle coherent sources.
The TRRS-ER-SAM algorithm was then applied to a study of N1m AEFs in 8 subjects aged 12-25 years. The study examined the effects of age, stimulus frequency, and right-sided monaural versus binaural stimulation on the N1m location, amplitude, and latency. It was found that age affected the N1m latency; stimulus frequency affected the N1m location, amplitude, and latency; and monaural versus binaural stimulation affected the N1m amplitude. In the context of these effects, the auditory pathway structure and neurophysiological changes due to maturation were discussed.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/11172 |
| Date | 30 July 2008 |
| Creators | Wong, Daniel |
| Contributors | Harrison, Robert |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
| Format | 7718437 bytes, application/pdf |
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