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Estudos visando a síntese total da Isodolastatina H / Study towards to total synthesis of isodolastatin H

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Publico-10940b.pdf: 1216468 bytes, checksum: bd1ea49c2bfdfa8789e58924c9513820 (MD5) / Nesta dissertação, são descritos os estudos visando a síntese total da isodolastatina H, um éster peptídico natural da família das dolastatinas com grande atividade citotóxica. O diferencial nesta sintese sobre as outras, foi a construcao das unidades gama-aminoacidos Dil e Dap, que foram obtidas via reacao de adicao de sais de crotil e aliltrifluoroboratos a L -prolinal e L -valinal, respectivamente. Os fragmentos foram posteriormente unidos por reacoes de esterificacao e amidacao. / This dissertation, are described the study towards to total synthesis of isodolastatin H, a natural peptide ester of dolastatin family with great citotoxicity activity. The main focus in this synthesis, is the construction of gama-aminoacid units Dil and Dap, obtained via addition reaction of crotyl and allyltrifluoroborate salts with L -prolinal and L-valinal, respectively. The junction of fragments was subsequently made from esterification and amidation reaction. / TEDE / BV UNIFESP: Teses e dissertações

Identiferoai:union.ndltd.org:IBICT/oai:repositorio.unifesp.br:11600/9606
Date27 February 2008
CreatorsGuarezemini, Alexandre Sardelli [UNIFESP]
ContributorsUniversidade Federal de São Paulo (UNIFESP), Stefani, Helio Alexandre [UNIFESP]
PublisherUniversidade Federal de São Paulo (UNIFESP)
Source SetsIBICT Brazilian ETDs
LanguagePortuguese
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis
Format108 p.
Sourcereponame:Repositório Institucional da UNIFESP, instname:Universidade Federal de São Paulo, instacron:UNIFESP
Rightsinfo:eu-repo/semantics/openAccess

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