abstract: Generating amorphous solid dispersions (ASDs) containing active pharmaceutical ingredients has become a favorable technique of emerging prominence to improve drug solubility and overall bioavailability. Cannabidiol (CBD) has now become a major focus in cannabinoid research due to its ability to serve as an anti-inflammatory agent, showing promising results in treating a wide array of debilitating diseases and pathologies. The following work provides evidence for generating homogenous glass phase amorphous solid dispersions containing 50% (w/w) up to 75% (w/w) CBD concentrations in the domain size of 2 – 5 nm. Concentrations up to 85% (w/w) CBD were concluded homogenous in the supercooled liquid phase in domain sizes of 20 – 30 nm. The results were obtained from polarized light microscopy (PLM), differential scanning calorimetry (DSC), as well as solution and solid-state NMR spectroscopy. / Dissertation/Thesis / Masters Thesis Biochemistry 2019
Identifer | oai:union.ndltd.org:asu.edu/item:53853 |
Date | January 2019 |
Contributors | Blass, Brandon Lewis (Author), Yarger, Jeff L (Advisor), Holland, Greg (Committee member), Moore, Gary (Committee member), Arizona State University (Publisher) |
Source Sets | Arizona State University |
Language | English |
Detected Language | English |
Type | Masters Thesis |
Format | 44 pages |
Rights | http://rightsstatements.org/vocab/InC/1.0/ |
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