Brain-reactive antibodies (BRA) increase in frequency with age in several mammalian species and may be involved in the pathogenesis of age-related dementia. In this experiment, the molecular specificity of BRA in mouse sera was determined using an immunoblot assay, and the relationship of BRA to longevity was studied by comparing the rate of formation of specific BRAs in diet restricted C57BL/6NNia, B6D2F1/NNia, and DBA/2NNia, genotypes which differ markedly in life-span.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc798378 |
| Date | 05 1900 |
| Creators | Apte, Vaijayanti |
| Publisher | University of North Texas |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | Text |
| Rights | Public, Copyright, Copyright is held by the author, unless otherwise noted. All rights |
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