Graft-versus-host reactions induced thymic epithelial cell injury, which was associated with a block in T cell maturation. No suppressor cells were detected in these thymuses. Thymic epithelial cell injury neither affected the acquisition of theta alloantigen nor interfered with homing of haemopoietic stem cells to the thymus, however, it impeded the ability of GVH thymuses to process the normal haemopoietic cells into mature T cells. / GVHBM cells repopulated the lymphoid organs of irradiated normal mice, and restored cell mediated humoral and splenic PHA, and ConA responses when transferred into T cell deprived mice. / The GVH reaction also induced B cell functional deficiencies. No suppressor cells were detected in the GVHBM. However, the colony forming ability of GVHBM cells was significantly decreased. / Thus, the GVH reaction resulted in a block of both T and B cell maturation which explained, at least in part, why GVH mice remained permanently immunosuppressed.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.77117 |
| Date | January 1980 |
| Creators | Seddik, Mona. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Physiology) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000137620, proquestno: AAINK54908, Theses scanned by UMI/ProQuest. |
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