Properties of sympathetic preganglionic neurones were examined in cat. Following horseradish peroxidase injection into the stellate ganglion, labelled neurones were in spinal segments C(,6)-T(,8) in regions of the intermediolateral nucleus, intermediate grey, central canal and ventral horn. Neurones located in the intermediolateral nucleus had a wide range of physiological properties, and, with the exception of basal activity, the properties studied failed to indicate subgroups. These neurones were also studied according to their sensitivities to substances implicated in synaptic transmission. (gamma)-Aminobutyric acid and glycine had inhibitory effects which were blocked by bicuculline and strychnine, respectively. Glutamate, aspartate and D-L- homocysteic acid exerted excitatory effects. Substance P, thyrotropin-releasing hormone, oxytocin and vasopressin also had excitatory effects; when the physiological properties of responsive vs unresponsive neurones were compared, those excited by oxytocin had shorter latencies of antidromic activation than unresponsive neurones. Thus, subgroups of neurones may be identified on the basis of their responsiveness to some substances and there may be a further breakdown when responsiveness is compared with physiological properties.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.71809 |
| Date | January 1982 |
| Creators | Backman, Steven B. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Physiology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000187079, proquestno: AAINK64375, Theses scanned by UMI/ProQuest. |
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