A recursive least-squares algorithm was developed to estimate respiratory mechanical parameters with high temporal resolution. This algorithm was used to investigate the time course of bronchoconstriction induced by intravenous histamine injection in the dog. The onset of the response of lung tissue resistance and elastance demonstrated a different time course than airway resistance. This was interpreted in terms of the sequential delivery of the drug first through the pulmonary and then the bronchial circulations. The time course of respiratory mechanical parameters among various alveolar capsules revealed two patterns of inhomogeneity development. The first one was random whereas the second one was progressive with dose. A mathematical derivation elucidated the negative tissue resistance frequently obtained at high levels of constriction. The time courses of respiratory resistance and elastance during bronchoconstriction were transient and scaled with dose. They were reproducible for repeated doses of histamine after indomethacin pre-treatment and were intrinsically modulated by the adrenergic sympathetic system and through the $ rm H sb2$ histamine receptors.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.41672 |
| Date | January 1993 |
| Creators | Lauzon, Anne-Marie |
| Contributors | Bates, J. H. T. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Physiology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001397509, proquestno: NN94663, Theses scanned by UMI/ProQuest. |
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