Mouse biliary glycoproteins (Bgp) are members of the carcinoembryonic antigen (CEA) family, a subfamily of the immunoglobulin superfamily. Nine similar but distinct mouse Bgp cDNA clones have been isolated and characterized. These Bgp isoforms encode polypeptides that contain multiple Ig domains, a single transmembrane domain and a short or long intracytoplasmic domain. Sequence analyses have demonstrated that Bgp isoforms are generated through complex alternative splicing of a single gene and allelic variation. Mouse Bgp proteins are highly expressed in the epithelial cells of the liver and the intestine and are implicated in diverse cellular functions including cell adhesion and bile acid transport, and are postulated to be involved in signal transduction. Investigation into the expression of mouse Bgp isoforms in normal and malignant tissues revealed that Bgp expression is downregulated in tumors. Furthermore, Bgp expression is influenced by transcriptional control mechanisms involving DNA methylation of the Bgp gene upstream regulatory regions.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.69769 |
| Date | January 1993 |
| Creators | Rosenberg, Madelaine |
| Contributors | Beauchemin, Nicole (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Biochemistry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001351827, proquestno: AAIMM91904, Theses scanned by UMI/ProQuest. |
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