Glutathione (GSH) is the most abundant antioxidant in the lung and plays an important protective role. The level of GSH in the airway surface liquid (ASL) is significantly reduced in cystic fibrosis (CF) patients, which may exacerbate the oxidative stress in the airway lumen induced by inflammation. GSH release may also be harmful to surface cells lining the airways if it reduces intracellular levels. The mechanisms of glutathione transport by airway epithelia are not known.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.19433 |
| Date | January 2003 |
| Creators | Chang, Colin A. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Physiology) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 002010349, Theses scanned by McGill Library. |
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