Coronary artery disease (CAD) is a major health concern for both developed and developing countries. With a heritability estimated at around 50%, there is a strong rationale to better define the genetic contribution of CAD. In order to do so, my thesis project consists in the genetic analysis of over 1400 individuals from the Saguenay Lac St-Jean region using 1536 single nucleotide polymorphisms in 103 candidate genes for CAD. Using this data, suggestive linkage for HDL cholesterol was found on chromosome 1 and several significant associations were observed with lipoprotein-related traits as well as adiponectin plasma concentration, including two novel associations.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.99196 |
| Date | January 2006 |
| Creators | Paré, Guillaume. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Human Genetics.) |
| Rights | © Guillaume Paré, 2006 |
| Relation | alephsysno: 002541488, proquestno: AAIMR28519, Theses scanned by UMI/ProQuest. |
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