Lymphocyte homing to the lymph nodes is a well defined process, dependent on the proper function of the homing receptors LFA-1 (one of the CD18 family of integrins) and L-selectin. However, the mechanism used by lymphocytes to accumulate in the spleen is still not understood. Both B lymphocytes and Natural Killer cells are prominent in the spleen. To investigate whether CD18 integrins or L-selectin play a role in B lymphocyte and NK cell homing to the spleen, mice genetically deficient in either of these molecules were analyzed by flow cytometry. The results of this study demonstrate that neither B lymphocytes nor NK cells require the CD18 family of integrins or L-selectin for entry into the spleen. Results of this study also showed that neither cell lineage required the CD18 integrins or L-selectin for egress from their sites of birth in the bone marrow.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.81355 |
| Date | January 2004 |
| Creators | Lejtenyi, Duncan |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Anatomy and Cell Biology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 002166501, proquestno: AAIMR06418, Theses scanned by UMI/ProQuest. |
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