The neuregulins (GGF/ARIA/NDF/Heregulin) are pleiotrophic growth factors that are involved in the development of the nervous system. The neuregulin receptors, erbB2, erbB3, erbB4, are members of the erbB/epidermal growth factor receptor family of receptor tyrosine kinases. Immunoblot analysis with antisera to peptides derived from the carboxy terminus of erbB2, erbB3, erbB4 demonstrate that the three receptors have unique spatial distribution in the brain and have expression patterns which are differentially regulated during development. At a cellular level, erbB2 and erbB4 are expressed by glia and neurons while expression of erbB3 is restricted to glia. We have also found that the distribution of erbB3 is developmentally regulated in avian muscle. Moreover, following denervation in adult rats, erbB3 and erbB4 protein levels are increased sciatic nerve, and in muscle, erbB3 is elevated at 16 and 24 days after denervation.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.23273 |
| Date | January 1995 |
| Creators | Francoeur, Jason |
| Contributors | Carbonetto, Salvatore (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Neurology and Neurosurgery.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001468294, proquestno: MM08014, Theses scanned by UMI/ProQuest. |
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