Return to search

The vervet regulator of G protein signaling 4 (RGS4) gene, a candidate gene for quantifiable behavioral dimensions associated with psychopathology : sequence, bioinformatic analysis, and association study of a novel polymorphism with social isolation

Regulators of G-protein coupled signaling (RGS) accelerate GTP hydrolysis and consequently influence signal termination. The RGS-4 gene has recently been reported to be implicated in a wide range of neuropsychiatric disorders including schizophrenia, Alzheimer's disease and addictions. / In this study, the vervet RGS-4 gene was sequenced on a CEQ 8000 genetic analysis system (Beckman Coulter) and characterized using molecular and bioinformatic tools. The obtained vervet sequence overall showed 95.3% sequence identity with the human RGS4 gene. / Thereafter, SNPs in the region encompassing the proximal promoter, exon 1 and the first 450 bp of intron 1 were identified by direct sequencing of 8 unrelated individuals. One of the identified SNPs, +35 [A/G], was genotyped in 155 juvenile vervets previously phenotyped for personality traits, including social isolation. Although preliminary association analysis fails to attain statistical significance (p=0.074), the sample size is small. Additional genotyping of phenotypically defined individuals needs to be undertaken.

Identiferoai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.84101
Date January 2004
CreatorsTrakadis, John
PublisherMcGill University
Source SetsLibrary and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada
LanguageEnglish
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation
Formatapplication/pdf
CoverageMaster of Science (Department of Human Genetics.)
RightsAll items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated.
Relationalephsysno: 002573145, proquestno: AAIMR28651, Theses scanned by UMI/ProQuest.

Page generated in 0.0018 seconds