Background. Tuberculin skin testing is an important tool for diagnosis and control of tuberculosis. The role of host genetics in responsiveness of pediatric tuberculosis patients to purified protein derivatives (PPD) has rarely been investigated. / Objective. To determine the impact of the candidate genes - Natural Resistance Associated Macrophage Protein 1 (NRAMP1), Vitamin D Receptor (VDR) and Interleukin 4 Receptor (IL4R) with other covariates on PPD reaction size in pediatric tuberculosis patients. / Methods. A family-based association study was conducted using eighty-three parent-child trios from a database of tuberculosis patients and their families from Texas, USA. / Results. Marker IL4Rrs1805010_GA was in linkage disequilibrium with PPD size (R2 = 16%; p = 0.0017). PPD size was a predictor of transmission of allele 1 ("G") of IL4Rrs1805010_GA with an OR (95% CI) of 1.9 (1.16, 3.14) per five millimeter average increase in PPD size adjusted for age of diagnosis. / Conclusions. This thesis provides evidence for the role of host genetics in PPD responsiveness in pediatric tuberculosis patients.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.81330 |
| Date | January 2004 |
| Creators | Eguale, Tewodros |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Epidemiology and Biostatistics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 002166401, proquestno: AAIMR06393, Theses scanned by UMI/ProQuest. |
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