Chronic obstructive pulmonary disease (COPD) is a composite of conditions that include an abnormal inflammatory response and emphysema. Cigarette smoking is the main risk factor for developing COPD and mouse models are widely used in the study of smoking induced emphysema. The C57BL/6 mouse strain develops airspace enlargement after chronic smoke exposure, with no change in lung mechanics. The broad objective of this thesis is to try to identify in mice, candidate genes that cause a difference in susceptibility to the development of the disease and to better understand the inflammatory process that occurs in response to smoke exposure. / A detailed introduction to COPD and proposed mechanisms of its pathophysiology are presented in Chapter I. / Chapter II consists of a manuscript containing data comparing the genetic expression profiles and inflammation in lung tissue of mice (C57BL/6) chronically exposed to cigarette smoke, with age-paired controls. The findings presented in Chapter II are discussed in greater detailed in Chapter III.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.99332 |
| Date | January 2006 |
| Creators | Cornejo Perales, Salomon Martin. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Experimental Medicine.) |
| Rights | © Salomon Martin Cornejo Perales, 2006 |
| Relation | alephsysno: 002566145, proquestno: AAIMR28477, Theses scanned by UMI/ProQuest. |
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