The TLE proteins are the mammalian homologs of Drosophila Groucho, a member of the Notch signaling pathway. Notch signaling controls the differentiation of a variety of tissues in invertebrates and vertebrates. To examine the role of the TLE genes in mammalian development, the expression of one of them, TLE 1, was analysed during mouse embryogenesis. This gene is expressed during a number of cell-determination events, including embryonic segmentation, central and peripheral neurogenesis, and epithelial differentiation. This pattern resembles groucho function in Drosophila and suggests that Groucho and TLE 1 protein may play similar developmental roles. These results also show that TLE 1 is co-expressed during a variety of cell - fate choices with several vertebrate homologs of genes implicated in the Drosophila Notch cascade, suggesting a role for the TLE 1 protein in mammalian Notch signaling.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.27306 |
| Date | January 1996 |
| Creators | Dehni, Ghassan. |
| Contributors | Stifani, Stefano (advisor), Miller, Freda (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Neurology and Neurosurgery.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001549776, proquestno: MQ29681, Theses scanned by UMI/ProQuest. |
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