A method is described that allows one to assess heritability of brain structures using magnetic resonance images (MRI). We have obtained MRI images for a group of identical twins and another group of fraternal twins. Each MRI image was segmented into white and gray matter then smoothed to estimate white and gray matter density at each 3D image element or voxel. At each voxel, we use the intraclass correlations of the two groups in order to compute a 3D image of a measure of heritability, as well as a test statistic for detecting those regions with significant heritability. To our knowledge the genetic variability of white and gray matter density has not been investigated on a voxel basis previously.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.31194 |
| Date | January 2001 |
| Creators | Bellera, Carine. |
| Contributors | Worsley, K. J. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Mathematics and Statistics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001810088, proquestno: MQ70383, Theses scanned by UMI/ProQuest. |
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