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Characterization of the Sac locus: Genetic basis of preference phenotypes for sodium saccharin and D-phenylalanine among inbred strains of mice

Two-bottle preference testing of inbred strains (129/J, BALB/cByJ, C3HeB/FeJ, C57BL/6J, and DBA/2J), a replicated half-diallele of Intercross (F1) progeny from these strains, (C57X129)X129 Backcross progeny, and (C57X129) X (C57X129) Intercross (F2) progeny were used to examine phenotypes for sodium saccharin (10$\sp{-3}$M) and d-phenylalanine (10$\sp{-1}$M). The genetic correlation from the inbred strains (0.80 $\pm$ 0.012) indicated shared genetic variance between the two phenotypes. Broad and narrow sense heritabilities were calculated for sodium saccharin (0.95 and 0.75) and for d-phenylalanine (0.96 and 0.74). The sodium saccharin phenotype was found to be monogenic in two segregating populations. Lack of significant linkage for this phenotype with the Mup-1 locus on chromosome four has been taken to indicate that Sac and dpa (on chromosome four) are independent loci. The d-phenylalanine phenotype appears to be determined largely by the Sac locus. / Source: Dissertation Abstracts International, Volume: 56-08, Section: B, page: 4631. / Thesis (Ph.D.)--The Florida State University, 1995.

Identiferoai:union.ndltd.org:fsu.edu/oai:fsu.digital.flvc.org:fsu_77550
ContributorsCapeless, Christopher Galvi., Florida State University
Source SetsFlorida State University
LanguageEnglish
Detected LanguageEnglish
TypeText
Format265 p.
RightsOn campus use only.
RelationDissertation Abstracts International

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