Most magnetic resonance imaging techniques offer tissue contrast but provide limited information regarding the variation of the magnetic resonance signal that exists on a smaller scale. The magnetic resonance signal arising from a heterogeneous tissue, such as spinal cord white matter, is the sum of signals from each tissue compartment within the imaging voxel. Analysis of this signal can better characterize the micro-anatomical heterogeneity tissue, white matter in particular. Many questions remain with regard to the compartmental contributions for the various types of magnetic resonance imaging (MRI) contrast. This project utilizes a variety of in vitro studies as well as simulations to better characterize the contribution of different water compartments to conventional MRI methods. Such an understanding of the complex combination of the various relaxation and exchange properties is important in developing an anatomical basis for interpreting magnetization transfer and T2 weighted images, particularly with respect to myelination.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-04172008-172151 |
| Date | 07 May 2008 |
| Creators | Dula, Adrienne Nicole |
| Contributors | Bill Valentine, Adam Anderson, Dan Gochberg, Dr. Mark Does, John Gore |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-04172008-172151/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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