Raman spectroscopy has the potential for providing differential diagnosis between dysplasia and benign cervix with high sensitivity and specificity. Two in vivo studies where designed to further evaluate the potential and improve the sensitivity of Raman spectroscopy to detect cervical dysplasia in a clinical setting. In the first study, the Raman spectral differences between the low grade dysplasia, high grade dysplasia, and benign cervix were characterized with a focus on low grade dysplasia, and a multi-class algorithm was used to classify spectra. The second study characterized spectral variability of the normal cervix due to factors such as hormonal status and the presence of previous disease. Additionally, Raman micro-spectroscopy was used to evaluate differences among histopathology classes and determine where the signal from in vivo experiments originates. These studies have shown that by taking normal variations of the cervix into consideration, Raman spectroscopy can successfully differentiate low grade dysplasia, high grade dysplasia, and benign cervix with high classification accuracy.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-07222008-160325 |
| Date | 27 July 2008 |
| Creators | Kanter, Elizabeth Marie |
| Contributors | Anita Mahadevan-Jansen, Duco E. Jansen, Gautam Rao, Yu Shyr, Rick Haselton |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu//available/etd-07222008-160325/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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