Clinically compatible ultra-short echo time (UTE) imaging sequences for quantitative T2-based bound and pore water imaging in bone were implemented and validated on a 3T human scanner and a 4.7T small bore system. Pore water images were generated by selectively saturating bound water signals with a T2-selective double adiabatic inversion pulse. Bound water images were generated by nulling the pore water signals with a T2-selective adiabatic inversion recovery preparation. In both cases, the magnetization preparation was integrated into a 3D UTE acquisition, with 16 radial spokes acquired per preparation. Images were acquired from human cadaveric femoral mid-shafts, from which isolated bone samples were subsequently extracted for non-imaging analysis using T2 spectroscopic measurements. The results showed a strong correlation between imaging-derived concentrations of bound and pore water and those determined from the isolated bone samples.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-03252013-092750 |
| Date | 15 April 2013 |
| Creators | Manhard, Mary Katherine |
| Contributors | Mark D. Does, Adam Anderson |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-03252013-092750/ |
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