A major challenge in endocrine surgery is the intraoperative identification of parathyroids during both thyroid and parathyroid surgery. Current localization techniques are mostly preoperative and are imprecise. Optical spectroscopy is fast and sensitive and has been used in many in vivo applications. Here, near-infrared (NIR) fluorescence is used to identify parathyroid glands during thyroid and parathyroidectomies. We investigated whether parathyroid tissue had unique optical signals that could be used to identify the parathyroid glands and differentiate them from other tissues in the neck intra-operatively. Fluorescence measurements were obtained from patients undergoing endocrine surgery at Vanderbilt University Medical Center. The intensity of the parathyroid signal was compared to the fluorescence of the surrounding tissue including the thyroid gland. In each case, the parathyroid had markedly higher levels of fluorescence. These results indicate that NIR fluorescence is potentially an excellent tool to locate parathyroid tissue during surgery.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-12102009-163623 |
| Date | 16 December 2009 |
| Creators | Paras, Constantine A |
| Contributors | Dr. Anita Mahadevan-Jansen |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu//available/etd-12102009-163623/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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