This thesis involves the development of an overnight high-resolution 3D diffusion kurtosis imaging protocol for ex vivo whole rat brain imaging. MRI acquisition parameters were optimized in order to obtain high-resolution, high-precision diffusion kurtosis imaging data. This included the programming and development of a 3D diffusion-weighted fast spin-echo pulse sequence. Image data from ex vivo rat brains were collected to verify the efficacy of the imaging protocol. Values of diffusion kurtosis parameters in normal rat brains were similar to those reported in previous imaging studies. Using this protocol, preliminary data were collected from a model of schizophrenia in rats. These data indicated the ability of the protocol to detect changes in diffusion kurtosis parameters that could correlate to changes in white matter microstructure.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-03252014-113144 |
| Date | 17 April 2014 |
| Creators | Kelm, Nathaniel D. |
| Contributors | Mark D. Does, Adam Anderson |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-03252014-113144/ |
| Rights | restricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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