Image guided transorbital endoscopic procedures have the potential to introduce new forms of therapy to the optic nerve, such as direct delivery of neuroprotective drugs for glaucoma treatment. This technique was confirmed to be possible and accurate in live animal studies, though featuring long procedure times. Navigation was enhanced by incorporating endoscopic video augmentation, which was demonstrated to significantly reduce procedure times while also improving accuracy in a series of phantom experiments performed by a diverse group of surgeons. In order to further the case for human application, procedure safety was assessed by characterizing the possible forces inflicted on the optic nerve in a phantom simulation. Measured forces implied reasonably low risk when considered in the context of human conditions, and surgeon experience and target nerve location were demonstrated to be significant factors. This research has advanced the case for application of image guided transorbital endoscopy to human therapy.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-04142014-131435 |
| Date | 29 April 2014 |
| Creators | DeLisi, Michael Paul |
| Contributors | Bennett A. Landman, Eva M. Harth, Louise A. Mawn, Michael I. Miga, Robert L. Galloway |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-04142014-131435/ |
| Rights | restricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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