Cord blood IgE has previously been studied as a possible predictor of asthma and allergic diseases. Results from different studies have been contradictory, and most have focused on high-risk infants and early infancy. Few studies have followed their study population into adulthood. This study assessed whether cord blood IgE levels and a family history of asthma were associated with, and could predict, asthma medication and allergy-related respiratory symptoms in adults. A follow-up was carried out in a Swedish birth cohort comprising 1701 consecutively born children. In all, 1661 individuals could be linked to the Swedish Prescribed Drug Register and the Medical Birth Register, and 1227 responded to a postal questionnaire. Cord blood IgE and family history of asthma were correlated with reported respiratory symptoms and dispensed asthma medication at 32–34 years. Elevated cord blood IgE was associated with a two- to threefold increased risk of pollen-induced respiratory symptoms and dispensed anti-inflammatory asthma medication. Similarly, a family history of asthma was associated with an increased risk of pollen-induced respiratory symptoms and anti-inflammatory medication. However, only 8% of the individuals with elevated cord blood IgE or a family history of asthma in infancy could be linked to current dispensation of anti-inflammatory asthma medication at follow-up. Elevated cord blood IgE and a positive family history of asthma were associated with reported respiratory symptoms and dispensed asthma medication in adulthood, but their predictive power was poor in this long-time follow-up. / <p>The status of this article was on the day of the defence date <em>Manuscript</em>.</p>
| Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:liu-85156 |
| Date | January 2013 |
| Creators | Vogt, Hartmut, Bråbäck, Lennart, Zetterström, Olof, Zara, Katalin, Fälth-Magnusson, Karin, Nilsson, Lennart |
| Publisher | Linköpings universitet, Pediatrik, Linköpings universitet, Hälsouniversitetet, Östergötlands Läns Landsting, Barn- och ungdomskliniken i Linköping, Linköpings universitet, Allergicentrum, Linköpings universitet, Hälsouniversitetet, Östergötlands Läns Landsting, Allergicentrum US, Linköpings universitet, Allergicentrum, Linköpings universitet, Hälsouniversitetet, Linköpings universitet, Pediatrik, Linköpings universitet, Hälsouniversitetet, Östergötlands Läns Landsting, Barn- och ungdomskliniken i Linköping, Linköpings universitet, Allergicentrum, Linköpings universitet, Hälsouniversitetet, Occupational & Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Article in journal, info:eu-repo/semantics/article, text |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | PLoS ONE, 1932-6203, 2013, 8:6, s. e66777.- |
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