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Previous issue date: 2010-10-21 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior, CAPES. / Whole-body extracts and proteins of mites are used for the diagnosis of allergic diseases in
humans and animals. The objective of the present study was to evaluate the biological activity
of commercial Dermatophagoides farinae and Blomia tropicalis allergenic extracts in dogs
with atopic dermatitis and to identify the allergens present in these extracts by serological
assays. For this purpose, 26 dogs were submitted to skin tests using commercial mite extracts
(ALK-Abell? or FDA Allergenic) and skin reactions were evaluated after 15 min. Allergenic
proteins present in the D. farinae and B. tropicalis extracts were identified by immunoblotting
using sera from allergic animals and anti-dog IgE conjugate. The results showed that 0.95 and
1.68 BU/mL of the commercial D. farinae and B. tropicalis extracts (ALK-Abell?),
respectively, are necessary to provoke a papule measuring 14 mm in diameter in susceptible
animals. Immunoblotting analysis of antigens present in the D. farinae extract (FDA
Allergenic) using sera from 10 allergic animals showed that 80% of the sera recognized a
band of approximately 102 kDa, 80% two bands of 52 to 76 kDa, 70% two bands larger than
225 kDa, 50% one band of approximately 76 kDa, 50% one band of approximately 225 kDa,
40% one band of 31 to 38 kDa, and 20% one band of 12 to 17 kDa. Immunoblotting of
antigens of the B. tropicalis extract (FDA Allergenic) showed that 50% of the sera recognized
two bands of 52 to 76 kDa. These results demonstrate the importance of the two house dust
mite species for the pathogenesis of canine atopic dermatitis in Brazil. In addition, the results
indicate allergens that should be present in allergenic extracts used for diagnosis and allergenspecific
immunotherapy. / CUNHA, Victor do Espirito Santo. Estudo da atividade biol?gica de extratos de corpo
total de ?caros da poeira domiciliar em c?es com dermatite at?pica e identifica??o
sorol?gica de al?rgenos. 2010. 49p Tese (Doutorado em Ci?ncias Veterin?rias, Sanidade
Animal). Instituto de Veterin?ria, Departamento de Parasitologia Animal, Universidade
Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2010.
Extratos de corpo total e prote?nas de ?caros s?o utilizados para diagn?stico de doen?as
al?rgicas em seres humanos e animais. O objetivo do presente trabalho foi determinar a
atividade biol?gica de extratos alerg?nicos comerciais de Dermatophagoides farinae e Blomia
tropicalis em c?es com dermatitite at?pica e identificar sorologicamente al?rgenos presentes
nesses extratos. Para tanto, 26 c?es foram testados intradermicamente com extratos comerciais
de ?caros (ALK-ABELL? ou FDA Allergenic) e as rea??es cut?neas avaliadas ap?s 15
minutos. Prote?nas alerg?nicas presentes nos extratos de D. farinae e B. tropicalis foram
identificadas por ?immunoblotting? utilizando-se soros dos animais al?rgicos e conjugado
anti-IgE canina. Os resultados obtidos mostraram que, para provocar uma p?pula com 14 mm
de di?metro nos animais sens?veis, s?o necess?rios 0,95 BU/mL e 1,68 BU/mL de extratos
comerciais de D. farinae e B. tropicalis (ALK-ABELL?), respectivamente. A an?lise por
?immunoblotting? dos ant?genos presentes no extrato de D. farinae (FDA Allergenic),
utilizando soros de dez animais al?rgicos, mostrou que 80% dos soros reconhecem uma banda
com peso molecular de aproximadamente 102 kDa; 80% duas bandas entre 52 e 76 kDa; 70%
duas bandas acima de 225 kDa; 50% uma banda com aproximadamente 76 kDa; 50% uma
banda com aproximadamente 225 kDa; 40% uma banda entre 31 e 38 kDa; e 20% uma banda
entre 12 e 17 kDa. A an?lise por ?immunoblotting? dos ant?genos do extrato de B. tropicalis
(FDA Allergenic) mostrou que 50% dos soros reconhecem duas bandas com pesos
moleculares entre 52 e 76 kDa. Esses resultados demonstram a import?ncia dessas duas
esp?cies de ?caros da poeira domiciliar na patog?nese da dermatite at?pica canina no Brasil,
assim como indicam al?rgenos que devem estar presentes nos extratos alerg?nicos utilizados
para diagn?stico e imunoterapia al?rgeno-espec?fica.
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/1148 |
| Date | 21 October 2010 |
| Creators | Cunha, Victor do Espirito Santo |
| Contributors | Faccini, Jo?o Luiz Horacio |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Ci?ncias Veterin?rias, UFRRJ, Brasil, Instituto de Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
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