To better understand how platelets behave when exposed to high shear stress, computational fluid dynamic (CFD) models for single-layer (uniform and constant) viscosity flow and two-layer (two distinct regions of different viscosities) viscosity flow were developed. The single-layer model, which represents common standard practice, did not predict the pressure drop correctly; the error produced from using the single-layer model was approximately 95%. However, the two-layer model produced results that were within 6% of the experimental results. Experimental results used to validate CFD models were obtained from data gathered by researchers at University Medical Center (UMC) in Jackson, MS. Using Fluent 6.2, simulations were performed that showed the characteristics of blood flow in a long stenosis. The beginning of the development of a blood damage model was also investigated. This thesis could provide researchers with information that will eventually allow the prediction of platelet activation and hemolysis.
| Identifer | oai:union.ndltd.org:MSSTATE/oai:scholarsjunction.msstate.edu:td-2004 |
| Date | 11 August 2007 |
| Creators | Ladner, Tammy Lynn |
| Publisher | Scholars Junction |
| Source Sets | Mississippi State University |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | Theses and Dissertations |
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