AbstractFactor VIII activity was studied in fifteen white laboratory rats, strain CFE, which were given subcutaneous doses of a solution containing estrogenic substances and progesterone over a six week period. A modified version of the thromboplastin generation test was used in conjunction with a factor VIII-deficient plasma to test for factor VIII activity.The rat population consisted of three groups, One group received a high concentration dosage level of the hormone The other group received a lower concentration dosage level of the hormone compound. The third group served as the control and received no hormone treatment. Each of the above groups contained five test animals.Factor VIII activity increased in all the experimental animals except one, as exhibited by a reduction in the coagulation time. No increase in factor VIII activity was observed in the control group. A significant statistical difference was observed between the experimental rats and those of the control. The 0.05 level of statistical significance was chosen for this study.Ball State UniversityMuncie, IN 47306
| Identifer | oai:union.ndltd.org:BSU/oai:cardinalscholar.bsu.edu:handle/180194 |
| Date | 03 June 2011 |
| Creators | Youtsey, John W. |
| Contributors | Pachall, Homer D. |
| Source Sets | Ball State University |
| Detected Language | English |
| Format | v, 77 leaves : ill. ; 28 cm. |
| Source | Virtual Press |
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