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A Study of the Interaction of Co-Insult Treatments with Methylmercuric Chloride and X-Irradiation and Demonstration of a Peroxide Induced Protective Mechanism

The initial purpose of this work was to investigate the interaction of methylmercuric chloride (MMC) and X-irradiation given as a co-insult upon the rat blood-brain barrier (BBB). The indicators used to determine BBB alterations were mortality and the in vivo tissue uptake of radioactive sulfate administered as 3 5S-sodium sulfate. The results of the interaction studies indicated a neutralization of effects when MMC and X-irradiation were given together. X-irradiation as a single insult generally caused an increase in sulfate uptake by the brain regions monitored, whereas MC treatment generally resulted in decreased sulfate uptake. The neutralization patterns following co-insult treatments were somewhat varied in the different brain regions, exhibiting cancellation of effects in some cases and overriding by one insult in other eases. From the data obtained by this work and in the literature, it is hypothesized that the P-L organelle system of the perivascular glia serves as a trap for MMC, preventing MMC from reaching the neurons. The system appears to proliferate in response to increased peroxides in the body fluids, thereby increasing tolerance to larger doses of MMC.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc501282
Date08 1900
CreatorsEarhart, James M.
ContributorsKester, Andrew S., Skinner, Charles Gordon
PublisherNorth Texas State University
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
Formatviii, 82 leaves : ill., Text
RightsPublic, Earhart, James M., Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved.

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