The treatment of Staphylococcus aureus bloodstream infections (SABSI) remains a major challenge. With an emphasis on complicated methicillin–sensitive S. aureus (MSSA), a comprehensive analysis of initial antibiotic treatment was conducted. The influence of treatment gaps on clinical outcomes were examined. Strategies were developed to improve the use of available antibiotics. Patient- and infection-related variables predictive for end-of-treatment failure included higher Charlson Comorbidity Index and healthcare-associated infection. Treatment variables of shorter duration of optimal targeted, shorter duration of optimal or adequate and lower TSE score were also predictive for end-of-treatment failure when tested separately in their own models. Strategies to optimize the treatment of complicated MSSA BSI at minimum should include: 1) Initiating at least an adequate therapy within 24 hours following the index blood culture draw and 2) Maintaining uninterrupted treatment, especially during the initial 7 days including at least 4 days of cloxacillin or cefazolin.
| Identifer | oai:union.ndltd.org:MANITOBA/oai:mspace.lib.umanitoba.ca:1993/30215 |
| Date | 13 January 2015 |
| Creators | Weber, Zhanni |
| Contributors | Zelenitsky, Sheryl (Pharmacy), Ariano, Robert (Pharmacy) Lagace-Wiens, Philippe (Medical Microbiology) Vercaigne, Lavern (Pharmacy) |
| Source Sets | University of Manitoba Canada |
| Detected Language | English |
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