Yes / As an important economic insect, Bombyx mori is also a useful model organism for lepidopteran insect. Integrins
are evolutionarily conserved fromsponges to humans, and play vital roles inmany physiological and pathological
processes. To explore their diverse functions of integrins in insect, eleven integrins including sixα and five β subunitswere
cloned and characterized fromsilkworm. Our results showed that integrins fromsilkwormown more
family members compared to other invertebrates. Among those α subunits, integrins α1, α2, and the other four
subunits belong to PS1, PS2, and PS3 groups, respectively. The β subunits mainly gather in the insect βν group
except the β1 subunit which belongs to the insect β group. Expression profiles demonstrated that the integrins
exhibited distinct patterns, but were mainly expressed in hemocytes. α1 and β2 subunits are the predominant
ones either in the embryogenesis or larva stages. Interestingly, integrins were significantly up-regulated after
stimulated by 20-hydroxyecdysone (20-E) in vivo. These results indicate that integrins performdiverse functions
in hemocytes of silkworm. Overall, our results provide a newinsight into the functional and evolutionary features
of integrins. / National Basic Research Programof China (No. 2012cb114603), the Research Fund for the Doctoral Program of Higher Education of China (20130182110003), the Natural Science Foundation of Chongqing (cstc2013jcyjys0007), and the Fundamental Research Funds for the Central Universities (SWU111014).
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/10480 |
| Date | 24 July 2014 |
| Creators | Zhang, K., Xu, M., Su, J., Sun, Z., Li, Y., Zhang, W., Hou, J., Shang, Lijun, Cui, H. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Accepted manuscript |
| Rights | © 2014 Elsevier. Reproduced in accordance with the publisher's selfarchiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/), CC-BY-NC-ND |
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