A method is reported for the bilateral, synchronous distribution of injected drugs to both sides of the brain simultaneously. Arguments have been made for the advantages of this approach over unilateral intracarotid injections for studying the direct effect of drugs on central synaptic sites.
Using this method, preliminary studies have been made of the effects of both adrenergic and cholinergic drugs on the activation of the electroencephalogram in both unanesthetized curarized cats and in cats subjected to mid-brain reticular coagulation. These studies indicate the possible co-existence of both adrenergic and cholinergic components in the mid-brain reticular formation and suggests that anatomically these sites probably are not identical. / Medicine, Faculty of / Anesthesiology, Pharmacology and Therapeutics, Department of / Graduate
| Identifer | oai:union.ndltd.org:UBC/oai:circle.library.ubc.ca:2429/40354 |
| Date | January 1957 |
| Creators | Ling, George M |
| Publisher | University of British Columbia |
| Source Sets | University of British Columbia |
| Language | English |
| Detected Language | English |
| Type | Text, Thesis/Dissertation |
| Rights | For non-commercial purposes only, such as research, private study and education. Additional conditions apply, see Terms of Use https://open.library.ubc.ca/terms_of_use. |
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