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Effects of Resistance and Aerobic Training on IGF-1 and BDNF Expression in a Murine Model of Alzheimer’s Disease

The primary purpose of this study was to investigate the effects of aerobic and
resistance training on BDNF and IGF-I expression in a 3xTg-AD mouse model of
Alzheimer’s disease. Twenty-four 3xTg-AD mice were randomly assigned to either an
aerobic (AT, n=8), resistance (RT, n=8), or control (CNT, n=8) group. Intervention
groups underwent 9 weeks of exercise training. Motor behavior and grip strength were
measured pre- and post- intervention. Our results showed a significant increase in
hippocampal BDNF expression in AT mice after a 9-week intervention. Further, AT mice
were found to have higher concentrations of IGF-I, and improved motor behavior when
compared to RT and CNT. No significant differences were observed in IGF-I
concentration between RT and other groups. RT improved grip strength after nine weeks
of training. These findings support the use of AT and RT as a tool to improve
comorbidities found in Alzheimer’s disease. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2018. / FAU Electronic Theses and Dissertations Collection

Identiferoai:union.ndltd.org:fau.edu/oai:fau.digital.flvc.org:fau_40750
ContributorsPena, Gabriel S. (author), Whitehurst, Michael (Thesis advisor), Florida Atlantic University (Degree grantor), College of Education, Department of Exercise Science and Health Promotion
PublisherFlorida Atlantic University
Source SetsFlorida Atlantic University
LanguageEnglish
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation, Text
Format56 p., application/pdf
RightsCopyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder., http://rightsstatements.org/vocab/InC/1.0/

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