This thesis describes studies assessing the ability of somatosensory evoked potentials
(SEPs) to predict outcome following severe brain injury by examining outcome and
determining the predictive value of SEPs directly and in comparison to alternative tests
in both patients and systematic reviews of the literature.
Outcome was assessed using a functional and quality of life measure. It changed over
time and was influenced by age, mechanism, timing and the type of outcome measure.
When 5 year functional outcome was used, sensitivity and specificity for the initial
SEPs were 63.2% and 93.3% with a positive predictive value of 92.3% for favourable
outcome and 66.7%, 94.7% and 90.9% for unfavourable outcome prediction. SEPs
predictive performance varied and was better in patients with 1 year outcomes, when
outcome was measured with the quality of life tool and in patients suffering hypoxicischaemic
encephalopathy. Importantly, only twelve false positives were identified in
the systematic review of 55 studies from 903 patients with bilaterally absent SEPs.
Eight of these false positives suffered focal lesions of the brain stem, large cerebral
fluid collections or recent decompressive craniectomy which cause SEPs to be absent
because of a mechanical disruption to the electrical signal.
Comparisons between SEPs and other tests in the patient cohort and wider literature
showed that SEPs were the best overall predictors of outcome but were outperformed
by some clinical tests in specific areas. Specificity for unfavourable outcome prediction
was better for ICP, CPP and the last pupillary response. In patients with any cause of
brain injury, the combination of SEPs and Motor responses provided the best
predictions for unfavourable outcome while for favourable outcome the best overall
prediction and specificity were achieved with a combination of either SEPs or Motor
responses and the best sensitivity with pupillary responses alone or a combination of
either SEPs or Pupillary responses.
The studies in this thesis provide a detailed evaluation of SEPs and showed that SEPs
have a place in the prediction of outcome, alone or in combination with existing tests.
Overall, they are superior to clinical tests and can be easily obtained at the bedside
and in the presence of pharmacological paralysis and analgesia/sedation.
| Identifer | oai:union.ndltd.org:ADTP/216614 |
| Date | January 2006 |
| Creators | Carter, Bradley Graham, n/a |
| Publisher | Swinburne University of Technology. |
| Source Sets | Australiasian Digital Theses Program |
| Language | English |
| Detected Language | English |
| Rights | http://www.swin.edu.au/), Copyright Bradley Graham Carter |
Page generated in 0.0023 seconds