Since 1942, when Bittner reported the incidence of non-induced tumors occuring in mice, strains of laboratory mice producing mammary carcinomas have been used as tools in research. Although not ideal for human studies, the histological and morophological similarities of the human and mouse mammary glands make it an excellent model to study the development of breast cancer. This study was performed to develop a rapid and consistent classification system for mouse mammary tissue, and compare various tumors to this system.Laboratory mice from the A and Balb/c strains were utilized in these studies. The three types of tumors developed in these mice were, non-induced, induced, and transplanted. Specimens of these tumors were collected and studied via light and electron microscopy for cellularchanges of tumor cells. These tumors were then classified according to the new system. These various tumors ranged from Class 0, which were normal cells, through gradual cellular changes to a Class IV, which were totally undifferentiated cells. host induced and non-induced tumors were Class III or IV, while the transplanted tumors were Class IV. This system facilitated the classification of mouse mammary tumors.
| Identifer | oai:union.ndltd.org:BSU/oai:cardinalscholar.bsu.edu:handle/182674 |
| Date | January 1982 |
| Creators | Adams, Rose Anna |
| Contributors | Hendrickson, Donald A. |
| Source Sets | Ball State University |
| Detected Language | English |
| Format | ii, vi, 49 leaves : ill. ; 28 cm. |
| Source | Virtual Press |
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