The transition from normal mammary development to the formation of aberrant cancerous tissues requires numerous mutations to occur. These alterations allow cancer cells to evade the usually strictly controlled pathways of survival, proliferation and self-renewal. The cell of origin for most tumours remains unknown but evidence that a sub-population of stem-like cells, termed cancer initiating cells, exists within solid cancers is strong.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:492869 |
| Date | January 2008 |
| Creators | Harrison, Hannah |
| Publisher | University of Manchester |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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