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Oestrogen and Notch Signalling in the Regulation of Human Breast cancer Initiating cells

The transition from normal mammary development to the formation of aberrant cancerous tissues requires numerous mutations to occur. These alterations allow cancer cells to evade the usually strictly controlled pathways of survival, proliferation and self-renewal. The cell of origin for most tumours remains unknown but evidence that a sub-population of stem-like cells, termed cancer initiating cells, exists within solid cancers is strong.

Identiferoai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:492869
Date January 2008
CreatorsHarrison, Hannah
PublisherUniversity of Manchester
Source SetsEthos UK
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation

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