Fetal Alcohol Syndrome (FAS) labels children with physical, mental and behavioral deficits exposed to alcohol in utero. Current research indicates that timing of alcohol exposure of the embryo/fetus is a critical determinant of the behavioral deficits associated with FAS. This study represents a model for binge drinking, in which C57BL mouse embryos were exposed to alcohol during 2 separate critical periods of brain development, gestational day (GD) 7 or 8. As adults, the offspring were tested to determine if loco-motor activity and emotional reaction to a novel environment had been affected. Significant differences due to treatment and sex were noted for both the number of urinations (p=.005 and .001, respectively) and fecal boli (p=.011 and .001, respectively). These results suggest that the quantity of alcohol exposure in utero on the developing brain as in this binge-drinking model is critical in terms of adverse effects on behavioral outcome for the offspring.
| Identifer | oai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etd-1096 |
| Date | 01 December 2001 |
| Creators | Nunley, Kevin Wade |
| Publisher | Digital Commons @ East Tennessee State University |
| Source Sets | East Tennessee State University |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | Electronic Theses and Dissertations |
| Rights | Copyright by the authors. |
Page generated in 0.0021 seconds