To determine whether polymorphisms in the GLUT2 and TAS1R2 genes are associated with dental caries, 80 Caucasian individuals were recruited. A clinical and radiographic examination determined 3 caries scores: DMFT (decayed, missing and filled teeth), DMFT+radiographs and ICDAS (International Caries Detection and Assessment System). Associations between genotype(s) and caries scores were analysed. A significant increase in DMFT scores was shown in GLUT2 polymorphism carriers (i.e. GLUT2 risk). Carriers of the TAS1R2 gene polymorphism (i.e. TAS1R2 resistant) consistently demonstrated lower caries scores. Caries scores were significantly decreased in the GLUT 2 Resistant/ TAS1R2 Resistant combined group as compared to the GLUT2 Risk/ TAS1R2 Risk combined groups. Variations in GLUT2 and TAS1R2 genes are associated with risk of dental caries. A possible compounded effect of having both genetic polymorphisms is suggested.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:OTU.1807/33379 |
| Date | 21 November 2012 |
| Creators | Chng, Tabitha |
| Contributors | Kulkarni, Gajanan |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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