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Previous issue date: 2011-02-24 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico - CNPq / PRIBUL, Bruno Rocha. Evaluation of Vancomycin Resistance and Susceptibility Profile
Bacteriocins of staphylococci isolated from bovine mastitis in Southern State of Rio de
Janeiro. 41p Thesis (Master of Veterinary Science). Instituto de Veterin?ria, Departamento
de Parasitologia Animal, Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2011.
Bacteria of the genus Staphylococcus are among the most implicated in the etiology of
mastitis. An additional difficulty in controlling bacterial infections by this genus is
represented by its frequent resistance to antibiotics. The glycopeptides (eg vancomycin)
appear as an alternative therapy because of the increasing strains of staphylococci resistant to
beta-lactams, which are the drugs of choice in these infections. Thus, glycopeptide resistance
represents a threat to the future of antimicrobial therapy in humans and animals. This study
aimed to evaluate the profile of vancomycin resistance pheno-genotypically in
Staphylococcus spp. milk samples from cows with mastitis. All 150 isolates (50 isolates of
Staphylococcus aureus, 50 isolates of Staphylococcus intermedius and 50 isolates of
Coagulase-negative Staphylococcus spp. (CNS) were evaluated using the tests of disk
diffusion, agar microdilution and detection of vanA e vanB genes. The antimicrobial
susceptibility test showed high resistance to beta-lactam antibiotics for all groups. In the disk
diffusion test, 24% of coagulase-positive isolates showed resistance to teicoplanin (24/100)
and 23% to vancomycin (23/100). In the agar microdilution test for detection of CIM, 16% of
the isolates were resistant to vancomycin (16/100). Among the resistant isolates in the agar
microdilution testing, 56.25% of the isolates (9 / 16) had MIC values ranging from 4-8?g/ml.
Staphylococcus coagulase-negative showed no resistance to the evaluated glycopeptides.
Genes for resistance to vancomycin were detected in 37.5% of vancomycin-resistant isolates
(6 / 16). To seek a correlation between the presence of glycopeptide resistance and the ability
of producing biofilm, tests were performed to characterize growth in Congo red agar and also
detection of the biofilm adherence test in microplates. It were detected 66.66% and 90, 00%,
respectively, of isolates producing biofilm. The production of "slime" presented no statistical
correlation with resistance to glycopeptides. The sensitivity profile of Staphylococcus spp.
was assessed against the bacteriocins produced by Lactobacillus paracasei, Lactobacillus
acidophilus and Lactobacillus fermentum. Lactobacillus paracasei bacteriocins presented the
highest inhibition capacity. / PRIBUL, Bruno Rocha. Avalia??o da Resist?ncia a Vancomicina e do Perfil de
Suscetibilidade a Bacteriocinas de Staphylococcus spp Isolados de Mastite Bovina da
Regi?o Sul do Estado do Rio de Janeiro. 41p Disserta??o (Mestrado em Ci?ncias
Veterin?rias). Instituto de Veterin?ria, Departamento de Parasitologia Animal, Universidade
Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2011.
As bact?rias do g?nero Staphylococcus est?o entre as mais implicadas na etiologia das mastites. Uma
dificuldade adicional no controle das infec??es bacterianas por este g?nero ? representada por sua
freq?ente resist?ncia aos antimicrobianos. Os glicopept?deos, como a vancomicina, aparecem como
uma alternativa terap?utica devido ao crescente aumento de cepas estafiloc?cicas resistentes aos
betalact?micos, que s?o os f?rmacos de elei??o nestas infec??es. Desse modo, a resist?ncia aos
glicopept?deos representa uma amea?a ao futuro da terapia antimicrobiana em humanos e animais. O
presente trabalho buscou avaliar o perfil de resist?ncia ? vancomicina em isolados de Staphylococcus
spp. oriundos de amostras de leite de vacas com mastite. Todos os 150 isolados estudados (50
Staphylococcus aureus, 50 Staphylococcus intermedius e 50 Staphylococcus spp. coagulase
negativos), foram avaliados atrav?s dos testes de difus?o em disco simples, microdilui??o em ?gar e
detec??o dos genes vanA e B. O teste de suscetibilidade antimicrobiana revelou elevada resist?ncia aos
beta-lact?micos para todos os grupos avaliados. No ensaio de difus?o em disco, os isolados coagulasepositivos
apresentaram um perfil de resist?ncia de 24% a teicoplanina (24/100) e 23% a vancomicina
(23/100). No teste de microdilui??o em ?gar para detec??o da CIM, 16% dos isolados apresentaram
resist?ncia ? vancomicina (16/100). Entre os isolados resistentes no teste de microdilui??o em ?gar,
56,25% dos isolados (9/16) apresentaram valores de CIM que variaram entre 4-8?g/ml. Os
Staphylococcus coagulase-negativos n?o apresentaram resist?ncia aos glicopeptideos. Os genes de
resist?ncia ? vancomicina foram detectados em 37,5% dos isolados vancomicina-resistentes (6/16).
Para se buscar uma correla??o entre a presen?a de resist?ncia aos glicopeptideos e a capacidade de
forma??o de biofilme foram realizados os testes de caracteriza??o de crescimento em ?gar vermelho
congo e detec??o de biofilme pelo teste de ader?ncia em microplacas, onde foram detectados 66,66% e
90,00% respectivamente, de isolados produtores de biofilme. A produ??o de ?slime? n?o apresentou
correla??o estat?stica com a resist?ncia aos glicopept?deos. O perfil de sensibilidade dos isolados de
Staphylococcus spp. foi avaliado frente as bacteriocinas produzidas pelos Lactobacillus paracasei,
Lactobacillus acidophillus e Lactobacillus fermentum. As bacteriocinas que apresentaram maior
capacidade de inibi??o frente aos Saphylococcus spp. testados foram as produzidas pelos
Lactobacillus paracasei
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/1142 |
| Date | 24 February 2011 |
| Creators | Pribul, Bruno Rocha |
| Contributors | Souza, Miliane Moreira Soares de |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Ci?ncias Veterin?rias, UFRRJ, Brasil, Instituto de Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
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