Local anesthesia is critical for performing corneal procedures in horses. Studying non- ophthalmic local anesthetics for corneal use is necessary because the efficacy and availability of ophthalmic preparations may be limited. This study aimed to evaluate the effects and potential adverse consequences of ropivacaine hydrochloride 0.5% and lidocaine hydrochloride 2% when applied topically to the corneas of eight healthy equids compared to an eyewash control. Data collection occurred over one week. Corneal touch threshold (CTT) was assessed via Cochet-Bonnet esthesiometry before and at pre-determined times after medication application. Ocular toxicity was assessed immediately following each trial and prior to the second trial using the semiquantitative preclinical ocular toxicity system (SPOTS). Ropivacaine and lidocaine significantly reduced CTT from baseline values. However, mean CTT and time to maximum anesthesia were not significantly different between drugs. No local side effects were seen. Ropivacaine and lidocaine could be used topically to reduce corneal sensitivity.
| Identifer | oai:union.ndltd.org:MSSTATE/oai:scholarsjunction.msstate.edu:td-7151 |
| Date | 10 May 2024 |
| Creators | Minaldi, Michael |
| Publisher | Scholars Junction |
| Source Sets | Mississippi State University |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | Theses and Dissertations |
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