<p>Tokom perioda rane laktacije brojni unutrašnji i<br />spoljašnji faktori vrše uticaj na produktivnost i<br />zdravlje mlečnih krava. Najznačajniji unutrašnji<br />faktori na početku laktacije su zapaljenski<br />procesi i metabolički stres. S obzirom da su<br />metaboličke i imunološke promene najčešći<br />okidač za nastanak bolesti, neophodno je bilo<br />ispitati da li postoji mogućnost regulisanja ovih<br />promena pomoću nesterodinih antiinflamatornih<br />lekova. Cilj ove doktorske disertacije je bio da<br />se ispita uticaj parenteralne primene<br />ketoprofena na metabolički status, inflamatorne<br />promene, odnos između metaboličkih i<br />inflamatornih promena kod krava posle teljenja,<br />kao i na proizvodnju mleka kod krava u ranoj<br />laktaciji. Za ogled je odabrano 30 krava.<br />Oglednoj grupi od 15 krava je i.m. aplikovan<br />ketoprofen u terapijskoj dozi (3mg/kg telesne<br />mase) tokom tri uzastopna dana nakon teljenja.<br />Kontrolna grupa od 15 krava je predstavljala<br />negativnu kontrolu. Uzorci krvi za analizu su<br />uzimani iz repne vene (vena coccygea) na dan<br />teljenja, u prvoj i drugoj nedelji posle teljenja.<br />Procena inflamacije je vršena na osnovu<br />određivanja koncentracije proteina akutne faze<br />(haptoglobina i fibrinogena) i proinflamatonih<br />citokina (interleukina-1α, faktora nekroze<br />tumora-alfa i interferona gama), dok je procenametaboličkog statusa vršena na osnovu određivanja vrednosti metaboličkih parametarau svim uzorcima krvnog seruma i u svim nedeljama ogleda. Ketoprofen primenjivan parenteralno kod krava posle teljenja je ublažio metabolički stres, uticao na smanjenje inflamatornih procesa i na smanjnje međusobne povezanosti i uticaja između metaboličkih i inflamatornih promena kod krava posle teljenja u poređenju sa netretiranim kravama, a imao je i pozitivan uticaj na proizvodnju mleka u ranoj laktaciji.</p> / <p>During the period of early lactation numerous<br />internal and external factors influence the health<br />and productivity of dairy cows. The most<br />important internal factors at the beginning of<br />lactation are inflammatory processes and<br />metabolic stress. Since the metabolic and<br />immunologic changes are the most common<br />trigger for the disease, it was necessary to<br />examine whether there is a possibility of<br />regulating these changes by using non-steroidal<br />anti-inflammatory drugs. The aim of this<br />doctoral thesis was to investigate the effect of<br />parenteral administration of ketoprofen in the<br />metabolic status, inflammatory changes, the<br />relationship between metabolic and<br />inflammatory changes in cows after calving and<br />milk production in cows in early lactation. This<br />study included 30 cows. Experimental group of<br />15 cows is treated i.m. ketoprofen administered<br />in a therapeutic dose (3 mg / kg body weight)<br />for three consecutive days after calving. A<br />control group of 15 cows accounted for a<br />negative control. Blood samples for analysis<br />were taken from the tail vein (vena coccygea)<br />on the day of calving, in the first and second<br />week after calving. Evaluation of inflammation<br />was based on the determination of the<br />concentration of acute phase proteins<br />(haptoglobin and fibrinogen) and<br />proinflamatonih cytokines (interleukin-1α,tumor necrosis factor-alpha and interferongamma),and the evaluation of the metabolic status performed on the basis of determining the value of metabolic parameters in a blood sample serum and in all the weeks of the experiment. Ketoprofen administered parenterally in cows after calving eased metabolic stress, had impact on reducing inflammatory processes and the decrease of interconnection and influence between metabolic and inflammatory changes in cows after calving compared with untreated cows, and had a positive impact on milk production in the early lactation.</p><p> </p>
| Identifer | oai:union.ndltd.org:uns.ac.rs/oai:CRISUNS:(BISIS)101043 |
| Date | 19 September 2016 |
| Creators | Kovačević Zorana |
| Contributors | Stojanovic Dragica, Cincović Marko, Jezdimirović Milanka, Belić Branislava, Đoković Radojica |
| Publisher | Univerzitet u Novom Sadu, Poljoprivredni fakultet u Novom Sadu, University of Novi Sad, Faculty of Agriculture at Novi Sad |
| Source Sets | University of Novi Sad |
| Language | Serbian |
| Detected Language | English |
| Type | PhD thesis |
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