El presente estudio tuvo como objetivo principal formular una crema dermocosmética a base de Mauritia flexuosa L. f. y Copaifera reticulata var. peruviana y comprobar su efecto regenerador en piel lesionada de ratones Mus musculus Balb c. Se evaluaron las características fisicoquímicas del aceite de aguaje y la oleorresina de copaiba. Posteriormente se diseñaron tres formulaciones: crema a base de aceite de Mauritia flexuosa L. f. “aguaje”, crema a base de oleorresina de Copaifera reticulata var. peruviana “copaiba” y una mezcla de ambas, en las cuales se realizaron estudios de estabilidad acelerada a la temperatura de 40 0C y 5 0C durante 120 días teniendo como parámetros análisis organolépticos (aspecto, color y olor), fisicoquímicos (pH, viscosidad) y carga microbiológica total. El efecto regenerador de la piel lesionada de las cremas dermocosmética se evaluó mediante el método tensiométrico y corroborado por estudios histológicos. Se emplearon ratones Mus musculus Balb c de 33 ± 2.7g de peso y como tratamientos las cremas dermocosméticas a base de aguaje al 8%, copaiba al 10% y una mezcla de ambas a las mismas concentraciones mencionadas, comparando los resultados con el grupo control (sin tratamiento) y con el grupo tratado con una crema comercial Cicalfate. Se obtuvo mayor efecto regenerador de la piel lesionada con la crema dermocosmética a base de aguaje y copaiba comprobada por presentar mayor porcentaje de cicatrización 57.4%, el cual se corroboró mediante el estudio histológico de la piel regenerada, donde se observaron inicios de reepitelización, tejido de granulación y aumento de colágeno en la dermis.
Palabras clave: Mauritia flexuosa L. f. “aguaje”, Copaifera reticulata var. peruviana “copaiba”, crema dermocosmética, efecto regenerador. / This present study was main objective to formulate a dermocosmetic cream based Mauritia flexuosa L. f. and Copaifera reticulata var. peruviana and to check its regenerative effect on damaged skin of mice Mus musculus Balb c. The physicochemical characteristics aguaje oil and copaiba oleoresin were evaluated. Subsequently, three formulations were designed: cream based oil of Mauritia flexuosa L. f. “aguaje”, cream based oleoresin of Copaifera reticulata var. peruviana "copaiba" and a mixture of both, which perfomed accelerated stability studies at the temperature of 40 0C and 5 0C for 120 days having as parameters organoleptic analysis (appearance, color and odor), physicochemical (pH, viscosity) and load microbial total. The regenerating effect in the injured skin was assessed by method tensiometric and corroborated by histological studies. Mus musculus Balb c mice of 33 ± 2.7g of weight were used and as treatments dermocosmetic creams based of aguaje 8%, copaiba 10% and a mixture of both at the same concentrations mentioned, comparing the results with the control group (untreated) and treated group with a commercial cream Cicalfate. The highest regenerative effect of damaged skin was obtained with the dermocosmetic cream based of aguaje and copaiba proven by to present higher percentage of healing 57.4%, which was confirmed by histological study of the regenerated skin, where were observed early epithelialization, tissue granulating and increasing collagen in the dermis.
Key words: Mauritia flexuosa L. f. "aguaje", Copaifera reticulata var. peruviana "copaiba", dermocosmetic cream, regenerating effect. / Tesis
| Identifer | oai:union.ndltd.org:Cybertesis/oai:cybertesis.unmsm.edu.pe:cybertesis/4454 |
| Date | January 2015 |
| Creators | Yaringaño Moreano, Joselyn Martha |
| Contributors | Jurado Teixeira, Bertha |
| Publisher | Universidad Nacional Mayor de San Marcos |
| Source Sets | Universidad Nacional Mayor de San Marcos - SISBIB PERU |
| Language | Spanish |
| Detected Language | Spanish |
| Type | info:eu-repo/semantics/bachelorThesis |
| Format | application/pdf |
| Source | Repositorio de Tesis - UNMSM, Universidad Nacional Mayor de San Marcos |
| Rights | info:eu-repo/semantics/openAccess |
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