No / Pure anhydrous polymorphs of carbamazepine were prepared by solution-enhanced dispersion with supercritical fluids (SEDSTM). Crystallization of the polymorphs was studied. Mechanisms are proposed that consider the thermodynamics of carbamazepine, supersaturation in the SEDSTM process, and the binary phase equilibria of organic solvents and the carbon dioxide antisolvent. -Carbamazepine was crystallized at high supersaturations and low temperatures, -carbamazepine crystallized from a methanol-carbon dioxide phase split, and -carbamazepine crystallized via nucleation at high temperatures and low supersaturation.
Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/3977 |
Date | January 2001 |
Creators | Edwards, Anthony D., Shekunov, Boris Yu., Kordikowski, Andreas, Forbes, Robert T., York, Peter |
Source Sets | Bradford Scholars |
Language | English |
Detected Language | English |
Type | Article, No full-text in the repository |
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