AMP-activated protein kinase (AMPK) is known as a pivotal cellular energy sensor,
mediating the adaptation to low energy levels by deactivating anabolic processes and activating
catabolic processes in order to restore the cellular ATP supply when the cellular AMP/ATP ratio is
increased. Besides this well-known role, it has also been shown to exert protective effects under
hypoxia. While an insufficient supply with oxygen might easily deplete cellular energy levels, i.e.,
ATP concentration, manifold other mechanisms have been suggested and are heavily disputed
regarding the activation of AMPK under hypoxia independently from cellular AMP concentrations.
However, an activation of AMPK preceding energy depletion could induce a timely adaptation
reaction preventing more serious damage. A connection between AMPK and the master regulator
of hypoxic adaptation via gene transcription, hypoxia-inducible factor (HIF), has also been taken
into account, orchestrating their concerted protective action. This review will summarize the current
knowledge on mechanisms of AMPK activation under hypoxia and its interrelationship with HIF.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:88971 |
| Date | 11 January 2024 |
| Creators | Dengler, Franziska |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2428, 10.3390/ijms21072428 |
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