Calcium signaling has been identified with triggering of gene transcriptions associated with learning and neuroprotection in neurons. Studies indicate that dysregulation of calcium signaling is correlated with severe Alzheimer Disease pathologies. A stable calcium wave or signal arising from triggers in dendritic synapses needs to reach soma with constant amplitude for proper functioning of neurons. In this study, we introduce "CalciumSim", a calcium dynamics simulator which works on dimensionally reduced model. Numerical analysis is conducted to obtain the best configuration of neuron geometry to make the code efficient and fast. Alongside, biologically important insights are derived by modulating and changing parameters of the simulation. The ability of "CalciumSim" to work with real neuron geometries allows user to study calcium signalling in a realistic model. / Mathematics
| Identifer | oai:union.ndltd.org:TEMPLE/oai:scholarshare.temple.edu:20.500.12613/7671 |
| Date | January 2022 |
| Creators | Borole, Piyush, 0000-0003-3327-5847 |
| Contributors | Queisser, Gillian, Seibold, Benjamin, Yilmaz, Atilla, Picone, Joseph |
| Publisher | Temple University. Libraries |
| Source Sets | Temple University |
| Language | English |
| Detected Language | English |
| Type | Thesis/Dissertation, Text |
| Format | 74 pages |
| Rights | IN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available., http://rightsstatements.org/vocab/InC/1.0/ |
| Relation | http://dx.doi.org/10.34944/dspace/7643, Theses and Dissertations |
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