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Previous issue date: 2011-02-28 / The regulation of the inflammatory response is essential to maintain
homeostasis. Several studies have been performed to search new drugs that
can contribute to avoiding or minimizing an excessive inflammatory process.
The aim of this study was to evaluate the effect of extracts of green algae
Caulerpa mexican in models of inflammation. In mice, the model of peritonitis
induced inflammatory zymosan pretreatment of mice with aqueous and
methanol extracts of C. mexican was able to reduce cell migration to the
peritoneal cavity. Treatment of mice with extracts of C. mexican also reduced
the ear edema induced by xylene and exerted inhibitory action on the migration
of leukocytes in inflammation-induced zymosan the air pouch, and timedependent
for the extracts tested in the model of ulcerative colitis induced by
DSS 3%, the extract methanol, but not the aqueous C. mexican, significantly
reduced the clinical symptoms of colitis, as well as the production of
proinflammatory cytokines in the culture of mouse colon, in the histological
analysis there was a slight reduction of inflammation in the intestinal mucosa.
We concluded that the administration of the extracts resulted in the reduction of
cell migration to different sites as well as reducing the edema formation induced
by chemical irritant. This study demonstrates for the first time the antiinflammatory
effect of aqueous and methanolic extracts from green marine
algae Caulerpa mexican / A regula??o da resposta inflamat?ria ? essencial para manter a
homeostase. Diversos estudos t?m sido realizados para a pesquisa de novas
drogas que possam contribuir para evitar ou minimizar um processo
inflamat?rio excessivo. O objetivo deste estudo foi avaliar o efeito de extratos
de algas verde Caulerpa mexicana em modelos de inflama??o. Em
camundongos, o modelo de peritonite inflamat?ria induzida por zimosam o
tratamento pr?vio de camundongos com extrato aquoso e metan?lico de C.
mexicana foi capaz de reduzir a migra??o celular para a cavidade peritoneal. O
tratamento dos camundongos com os extratos da C. mexicana tamb?m
diminuiu o edema de orelha induzido por xilol e exerceu a??o inibit?ria da
migra??o de leuc?citos em inflama??o induzido pelo zimosam na bolsa de ar,
sendo tempo-dependente para os extratos testados, no modelo de colite
ulcerativa induzida por DSS 3%, o extrato metan?lico, mas n?o o aquoso da C.
mexicana, reduziu de forma significativa o quadro cl?nico da colite, como
tamb?m a produ??o de citocinas pr?-inflamat?rias na cultura do c?lon do
camundongo, na an?lise histol?gica houve uma leve redu??o da inflama??o na
mucosa intestinal. Conclu?mos que a administra??o dos extratos resultou na
redu??o da migra??o de c?lulas para diferentes modelos experimentais, bem
como reduzir a forma??o de edema induzida por irritante qu?mico. Este estudo
demonstra pela primeira vez o efeito anti-inflamat?rio do extrato aquoso e
metan?lico da alga verde marinha Caulerpa mexicana
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/13461 |
| Date | 28 February 2011 |
| Creators | Bitencourt, Mariana Ang?lica Oliveira |
| Contributors | CPF:61689858400, http://lattes.cnpq.br/6501426772186111, Santos, Cl?udio Roberto Bezerra dos, CPF:95365940482, http://lattes.cnpq.br/9068173172525408, Sales, Val?ria Soraya de Farias, CPF:25069144472, http://lattes.cnpq.br/8525532896559374, Souto, Janeusa Trindade de |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Ci?ncias Farmac?uticas, UFRN, BR, Bioan?lises e Medicamentos |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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