Cancer targeted imaging plays an important role in cancer diagnosis. It allows us to rapidly evaluate tumor responses to certain treatments. Peptide-based imaging probes have been widely used in cancer targeted imaging. With the development of phage display technology, a great number of peptides have been identified specifically targeting to tumor cells in vitro and in vivo. However, due to peptides small size and relatively low binding affinity, it is difficult to identify the target of peptides. This thesis research is focusing on: i). identifying the target of specific peptide HVGGSSV, which bind to radiation responsive tumors, by utilizing several affinity purification techniques especially the phage display screening; and validating the target as a marker for evaluation of radiation treatment; ii). exploring the biological functions of the targeting protein.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-03252011-131133 |
| Date | 07 April 2011 |
| Creators | Wang, Hailun |
| Contributors | Zhaozhong Han |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-03252011-131133/ |
| Rights | restricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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