Myeloid derived suppressor cells (MDSCs) play an important role in cancer progression, and elucidating the mechanisms involved in the accumulation and function of these cells is important. Preliminary data indicated that Rgs2 may have a role in MDSC production and differentiation. As such, its role in hematopoiesis and myeloid cell differentiation was examined. Overall, hematopoiesis was not affected by loss of Rgs2, and MDSC production and heterogeneity in the spleen were not altered. However, Rgs2 deficiency in MDSCs abrogated the tumor promoting roles of these cells, accompanied by drastically decreased MCP-1 production, and subsequent effects on endothelial cells and leukocytes. Together, these data suggest that Rgs2 affects the tumor promoting functions of MDSCs through mediating MCP-1 production. In targeting the signaling pathway involving Rgs2 in MDSCs, we may be able to promote an anti-tumor response to cancer, enhancing patient outcome.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-03292011-102758 |
| Date | 29 March 2011 |
| Creators | Boelte, Kimberly C |
| Contributors | Charles Lin, Lynn Matrisian, Scott Hiebert, Stephen Brandt |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-03292011-102758/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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