VAPB (VAMP-associated protein B) is an endoplasmic reticulum protein that regulates multiple biological functions. VAPB protein expression is elevated in human breast cancers and correlates with poor prognosis. Despite aberrant expression of VAPB in breast cancer, its function in tumor cells is poorly understood. In this dissertation we demonstrate the causal role between VAPB and breast cancer, specifically in three areas (1) cell growth (2) invasion and (3) tumor growth in vivo. Additionally, we provide mechanistic evidence that VAPB regulates breast tumor cell proliferation and invasion through enhanced ATK activity and vesicle mediated protein secretion.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-11292012-144810 |
| Date | 07 December 2012 |
| Creators | Rao, Meghana Nallamala |
| Contributors | Robert Coffey, Jin Chen, Albert Reynolds, Rebecca Cook |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-11292012-144810/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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